SB 242084
SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist with pKi of 9.0, 100- and 158-fold selectivity over the closely related 5-HT2B and 5-HT2A subtypes; also displays >100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors; inhibits 5-HT-stimulated phosphatidylinositol hydrolysis with pKb of 9.3 in cell-baed assays; potently inhibits m-chlorophenylpiperazine (mCPP) -induced hypolocomotion in rats, with an ID50 of 0.11 mg/kg i.p., and 2.0 mg/kg p.o.
Product Specifications
CAS Number
181632-25-7
Product Name Alternative
SB-242084 | SB242084
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 44 mg/mL
Smiles
CC1=CC2=C (C=C1Cl) N (CC2) C (=O) NC3=CN=C (C=C3) OC4=C (N=CC=C4) C.Cl.Cl
Molecular Formula
C21H19ClN4O2
Molecular Weight
467.78
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-[6-[ (2-methyl-3-pyridinyl) oxy]-3-pyridinyl]-
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