ARV-825
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome; shows more significant and longer lasting c-MYC suppression than small molecule inhibitors (JQ1, OTX015) ; leads to a superior effect on BL cells proliferation suppression.Breast Cancer, Preclinical.
Product Specifications
CAS Number
1818885-28-7
Product Name Alternative
ARV 825 | ARV825
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=CC=C (OCCOCCOCCOCCNC2=CC=CC (C (N3C (CC4) C (NC4=O) =O) =O) =C2C3=O) C=C1) C[C@H]5C6=NN=C (C) N6C7=C (C (C) =C (C) S7) C (C8=CC=C (Cl) C=C8) =N5
Molecular Formula
C46H47ClN8O9S
Molecular Weight
923.4316
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- ((S) -4- (4-chlorophenyl) -2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl) -N- (4- (2- (2- (2- (2- ((2- (2,6-dioxopiperidin-3-yl) -1,3-dioxoisoindolin-4-yl) amino) ethoxy) ethoxy) ethoxy) ethoxy) phenyl) acetamide
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