PFI-3
PFI-3 is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM; shows high selectivity over other bromodomains; exposure of embryonic stem cells to PFI-3 led to deprivation of stemness and deregulated lineage specification; markedly enhances the differentiation of trophoblast stem cells; attenuates adipocyte differentiation and dramatically decreases lipid accumulation; a first in class chemical probe for Family VIII bromodomains.
Product Specifications
CAS Number
1819363-80-8
Product Name Alternative
PF-6687252 | PF-06687252
Purity
>98% (HPLC)
Solubility
DMSO: 32.1 mg/mL (100 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
OC1=C (C (/C=C/N2[C@H] (C3) CN (C4=NC=CC=C4) [C@H]3C2) =O) C=CC=C1
Molecular Formula
C19H19N3O2
Molecular Weight
321.38
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -1- (2-hydroxyphenyl) -3- ((1R,4R) -5- (pyridin-2-yl) -2,5-diazabicyclo[2.2.1]heptan-2-yl) prop-2-en-1-one
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