INCB057643
INCB057643 is a novel potent, selective, orally bioavailable BET inhibitor; shows more effectivity against androgen-dependent (VCaP and LNCaP) than androgen-independent (DU145 and PC3) cells with IC50 of 500 nM, respectively; significantly causes inhibition of tumor growth in mice bearing 22Rv1 tumor xenografts.Solid Tumors Phase 2 Clinical.
Product Specifications
CAS Number
1820889-23-3
Product Name Alternative
INCB 057643
Purity
>98% (HPLC)
Solubility
DMSO : 62.5 mg/mL 150.44 mM
Smiles
CN (C (C (C) (C) O1) =O) C2=C1C (C (C3=C4NC=C3) =CN (C) C4=O) =CC (S (C) (=O) =O) =C2
Molecular Formula
C20H21N3O5S
Molecular Weight
415.464
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,2,4-trimethyl-8- (6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl) -6- (methylsulfonyl) -2H-benzo[b][1,4]oxazin-3 (4H) -one
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