SBI-0640756
SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex; impairs the eIF4F complex assembly and attenuates growth of BRAF-resistant and BRAF-independent melanomas; inhibits the growth of NRAS, BRAF, and NF1-mutant melanomas in vitro, delays the onset and reduces the incidence of Nras/Ink4a melanomas in vivo; attenuates the formation of BRAFi-resistant human tumors combined with PLX4720 in vivo.
Product Specifications
CAS Number
1821280-29-8
Product Name Alternative
SBI-756
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 26 mg/mL
Smiles
O=C1NC2=C (C=C (Cl) C=C2) C (C3=CC=CC=C3) =C1C (/C=C/C4=CC (F) =CN=C4) =O
Molecular Formula
C23H14ClFN2O2
Molecular Weight
404.8209
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -6-chloro-3- (3- (5-fluoropyridin-3-yl) acryloyl) -4-phenylquinolin-2 (1H) -one
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