AZD-0156
AZD-0156 (AZD0156, AZD 0156) is a potent, highly selective and orally bioavailable ATM inhibitor; exhibits antitumoral activity, both reducing tumor burden and preventing tumors from growing in an immunocompetent allograft mouse model of AML.Solid Tumors Phase 1 Clinical (In Vitro) :AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.
Product Specifications
CAS Number
1821428-35-6
Product Name Alternative
AZD0156 | AZD 0156
Purity
>98% (HPLC)
Solubility
DMSO: 6.2 mg/mL (Need ultrasonic and warming)
Smiles
O=C (N1C2CCOCC2) N (C) C3=C1C4=CC (C5=CC=C (OCCCN (C) C) N=C5) =CC=C4N=C3
Molecular Formula
C26H31N5O3
Molecular Weight
461.556
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3- (dimethylamino) propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1- (tetrahydro-2H-pyran-4-yl) -
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