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Mithramycin A

A tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA; binds to the minor groove of DNA at GC-rich sites, induces cancer cell apoptosis and metastasis.

Product Specifications

CAS Number

18378-89-7

Product Name Alternative

Plicamycin | PA 144 | NSC 24559

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : ≥ 100 mg/mL (92.15 mM)

Smiles

O=C1[C@@H] (O[C@H]2C[C@@H] (O[C@H]3C[C@@H] (O[C@H]4C[C@] (C) (O) [C@H] (O) [C@@H] (C) O4) [C@H] (O) [C@@H] (C) O3) [C@H] (O) [C@@H] (C) O2) [C@H] ([C@H] (OC) C ([C@@H] (O) [C@H] (O) C) =O) CC5=C1C (O) =C6C (O) =C (C) C (O[C@H]7C[C@@H] (O[C@H]8C[C@@H] (O) [C@H] (O) [C@@H] (C) O8) [C@H] (O) [C@@H] (C) O7) =CC6=C5

Molecular Formula

C52H76O24

Molecular Weight

1085

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

(2S,3S) -3- ((1S,3S,4R) -3,4-dihydroxy-1-methoxy-2-oxopentyl) -2- (((2S,4R,5R,6R) -4- (((2S,4R,5S,6R) -4- (((2S,4S,5R,6R) -4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl) oxy) -5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl) oxy) -5-hydroxy-6-methyltetrahydro-2H-pyran-

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