CM-272
CM-272 (CM272) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 8 nM and 382 nM for G9a and DNMT1, respectively; also inhibits DNMT3A/3B/GLP with IC50 of 85/1,200/2 nM, respectively; inhibits cell proliferation and promotes apoptosis in different haematological neoplasias (AML, ALL and DLBCL) ; significantly prolongs survival of AML, ALL and DLBCL xenogeneic models.
Product Specifications
CAS Number
1846570-31-7
Product Name Alternative
CM272 | CM 272
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (261.16 mM)
Smiles
CC1=CC=C (O1) C2=NC3=CC (=C (C=C3C (=C2) NC4CCN (CC4) C) OC) OCCCN5CCCC5
Molecular Formula
C28H38N4O3
Molecular Weight
478.637
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-methoxy-2- (5-methylfuran-2-yl) -N- (1-methylpiperidin-4-yl) -7- (3- (pyrrolidin-1-yl) propoxy) quinolin-4-amine
Available Sizes
Frequently Asked Questions
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