SBI-0206965
SBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM; displays 7-fold less potency for ULK2 (IC50=711 nM) ; inhibits Beclin1 Ser15 and Vps34 Ser249 phosphorylation to comparable extents in HEK-293T cells; suppresses autophagy induced by mTOR inhibition and prevents ULK1-dependent cell survival; greatly synergized with mTOR inhibitors to kill tumor cells.
Product Specifications
CAS Number
1884220-36-3
Product Name Alternative
SBI 0206965 | SBI0206965
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC) C1=CC=CC=C1OC2=NC (NC3=CC (OC) =C (OC) C (OC) =C3) =NC=C2Br
Molecular Formula
C21H21BrN4O5
Molecular Weight
489.3192
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- ((5-bromo-2- ((3,4,5-trimethoxyphenyl) amino) pyrimidin-4-yl) oxy) -N-methylbenzamide
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