BRD-4770
A SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs), including G9a, in biochemical assays and in cells; decreases H3K9 trimethylation level in PANC-1 cells with EC50 of 5 uM; induces senescence, and inhibits both anchorage-dependent and -independent proliferation in PANC-1 cells; also increases LC3-II levels and the autophagosome number in PANC-1 cells combined with Gossypol.
Product Specifications
CAS Number
1374601-40-7
Product Name Alternative
BRD 4770 | BRD4770
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (C1=CC=C2C (N=C (NC (C3=CC=CC=C3) =O) N2CCCC4=CC=CC=C4) =C1) OC
Molecular Formula
C25H23N3O3
Molecular Weight
413.4684
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Benzimidazole-5-carboxylic acid, 2- (benzoylamino) -1- (3-phenylpropyl) -, methyl ester
Available Sizes
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