GNE-0877
GNE-7915 is a highly potent, selective, brain-penetrating LRRK2 inhibitor with Ki of 0.6 nM (LRRK2 G2019S), pLRRK2 cell IC50 of 3 nM; induces abnormal cytoplasmic accumulation of secretory lysosome-related organelles known as lamellar bodies in type II pneumocytes of the lung in nonhuman primates, but no lysosomal abnormality in the kidney.
Product Specifications
CAS Number
1374828-69-9
Product Name Alternative
GNE0877
Purity
>98% (HPLC)
Solubility
DMSO: 62 mg/mL (182.7 mM) ; Ethanol: <1 mg/mL; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
CC (N1N=C (C) C (NC2=NC=C (C (F) (F) F) C (NC) =N2) =C1) (C) C#N
Molecular Formula
C14H16F3N7
Molecular Weight
339.326
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-methyl-2- (3-methyl-4- ((4- (methylamino) -5- (trifluoromethyl) pyrimidin-2-yl) amino) -1H-pyrazol-1-yl) propanenitrile
Available Sizes
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