ACY-738
ACY-738 (ACY738) is a potent and specific HDAC6 inhibitor (IC50=1.7 nM) with improved brain bioavailability; displays 60-1500 fold selectivity over class I HDACs; induces dramatic increase in α-tubulin acetylation in brain and stimulates mouse exploratory behaviors; increases the innervation of the neuromuscular junctions in the gastrocnemius muscle and improves the motor and sensory nerve conduction in the mutant HSPB1-induced CMT2 mouse model.Depression Preclinical.
Product Specifications
CAS Number
1375465-91-0
Product Name Alternative
ACY738 | ACY 738
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
O=C (C1=CN=C (NC2 (C3=CC=CC=C3) CC2) N=C1) NO
Molecular Formula
C14H14N4O2
Molecular Weight
270.2866
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-Pyrimidinecarboxamide, N-hydroxy-2-[ (1-phenylcyclopropyl) amino]-
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
TTLL12 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
KLRC1 Antibody - N-terminal region : FITC (ARP61289_P050-FITC)
SAMHD1/MOP5 Recombinant Antibody, Biotin Conjugated
SAMHD1/MOP5 Recombinant Antibody, Biotin Conjugated