Vps34-IN-1
Vps34-IN-1 is a potent, selective inhibitor of class III PI3K Vps34 with IC50 of 25 nM, does not inhibit class I and II PI3Ks, as well as a broad panel of protein kinases or lipid kinases; rapidly reduces endosomal PtdIns (3) P levels, induces a rapid ~50-60% loss of SGK3 phosphorylation in cells, does not inhibit activity of the SGK2 isoform; Vps34-IN1 is a useful probe to delineate physiological roles of the Vps34.
Product Specifications
CAS Number
1383716-33-3
Product Name Alternative
Vps34-IN1
Field of Research
Signal Transduction
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 31 mg/mL
Smiles
OC (C) (C) CNC (N=C1CC2CC2) =NC=C1C3=CC=NC (NC4=CC=NC (Cl) =C4) =N3
Molecular Formula
C21H24ClN7O
Molecular Weight
425.9146
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Propanol, 1-[[2-[ (2-chloro-4-pyridinyl) amino]-4'- (cyclopropylmethyl) [4,5'-bipyrimidin]-2'-yl]amino]-2-methyl-
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