Lys05
Lys05 (Lys01 trihydrochloride, PS-1001) is the water-soluble salt of Lys01, is a 10-fold more potent lysosomal autophagy inhibitor than hydroxychloroquine (HCQ) ; shows IC50 values of 3.6, 3.8, 6 and 7.9 uM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay; more potently accumulates within and deacidifies the lysosome, resulting in impaired autophagy and tumor growth; enhances sunitinib-mediated suppression of clear cell ovarian carcinoma (CCOC) cell viability.
Product Specifications
CAS Number
1391426-24-6
Product Name Alternative
Lys-05 | Lys 05 | Lys01 trihydrochloride | PS-1001
Purity
>98% (HPLC)
Solubility
DMSO: 6.4 mg/mL, Need Ultrasonic; Water: 3 mg/mL (5.5 mM) ; Ethanol: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
CN (CCNC1=CC=NC2=CC (Cl) =CC=C12) CCNC3=CC=NC4=CC (Cl) =CC=C34.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C23H26Cl5N5
Molecular Weight
549.75
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N2- (7-Chloro-4-quinolinyl) -N1-[2-[ (7-chloro-4-quinolinyl) amino]ethyl]-N1-methyl-1,2-ethanediamine trihydrochloride
Available Sizes
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