Thiostrepton
Thiostrepton is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders. (In Vitro) :Thiostrepton (0.01-1000 μM; 48 hours) suppresses cell viability in A2780 and HEC-1A. (In Vivo) :Thiostrepton (i.p.; 17 mg/kg) reduces the tumorigenicity of Ewing's sarcoma (EWS) cells. Tumor volumes in control mice have increased ~6-fold from the initiation of treatment, while their Thiostrepton-treated counterparts increase only ~1.7-fold, exhibiting a ~3.5-fold reduction, relative to controls.
Product Specifications
CAS Number
1393-48-2
Product Name Alternative
Bryamycin | NSC 81722 | NSC 170365 | Thiactin | Thiostreptin A
Purity
>98% (HPLC)
Solubility
DMSO: 40mg/mL
Smiles
NC[S=N]H (C) C (O) =O
Molecular Formula
C72H85N19O18S5
Molecular Weight
1664.89
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Thiostrepton
Available Sizes
Frequently Asked Questions
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SGTA (Small Glutamine-rich Tetratricopeptide Repeat-containing Protein alpha, Alpha-SGT, Vpu-binding protein, UBP, SGT, SGT1)
