GNE-317
GNE-317 (GNE317) is a potent, brain penepenetrant, dual PI3K/mTOR inhibitor having physicochemical properties predictive of low efflux by P-gp and BCRP; inhibits the cell proliferation of GBM6, 10, 22, and 84 with IC50 of 0.59, 0.72, 0.26, and 3.49 uM, respectively; markedly inhibits the PI3K pathway in mouse brain, causing 40% to 90% suppression of the pAkt and pS6 signals, significantly inhibits tumor growth in orthotopic models of glioblastoma multiforme (GBM) .
Product Specifications
CAS Number
1394076-92-6
Product Name Alternative
GNE317
Purity
>98% (HPLC)
Solubility
DMSO: 20 mg/mL
Smiles
NC1=NC=C (C2=NC (N3CCOCC3) =C4C (C=C (C5 (OC) COC5) S4) =N2) C=N1
Molecular Formula
C19H22N6O3S
Molecular Weight
414.4814
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Pyrimidinamine, 5-[6- (3-methoxy-3-oxetanyl) -7-methyl-4- (4-morpholinyl) thieno[3,2-d]pyrimidin-2-yl]-
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