Mertansine
Mertansine (DM1) is a tubulin inhibitor; thiol-containing maytansinoid that create an antibody-drug conjugate (ADC) ; an ADC payload. (In Vitro) :Mertansine is a strong antiproliferative chemotherapeutics toward over 60 types of cancer cell lines.Mertansine (0-1 μg/mL) shows antitumor activity in malignant B16F10 melanoma cells, and inhibits tumor cell growth by inhibiting mitosis when combined with DTX. (In Vivo) :Mertansine (DM1) has a low maximum-tolerated dose (MTD) of 1 mg/kg.
Product Specifications
CAS Number
139504-50-0
Product Name Alternative
DM1 | Maytansinoid DM1 | DM-1 | Maytansinoid DM-1
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 83.33 mg/mL
Smiles
Molecular Formula
C35H48ClN3O10S
Molecular Weight
738.2877
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Maytansine, N2'-deacetyl-N2'- (3-mercapto-1-oxopropyl) -
Available Sizes
Explore Other Products
Browse additional items from our catalog
Anti-Cathepsin E/CTSE Antibody Picoband® (HRP Conjugate)
Recombinant Synechococcus sp. Cytochrome c-550 (psbV)
Recombinant Synechococcus sp. Cytochrome c-550 (psbV)