PE859
PE859 is a novel, orally active tau aggregation inhibitor that inhibits the heparin-induced aggregation of both 3RMBD and full length tau with IC50 of 0.81 uM and 2.23 uM, respectively; also inhibits amyloid β (Aβ) aggregation with IC50 of 1.2 uM; significantly reduces sarkosyl-insoluble aggregated tau along with the prevention of onset and progression of the motor dysfunction in JNPL3 P301L-mutated human tau transgenic mice.
Product Specifications
CAS Number
1402727-29-0
Product Name Alternative
PE-859 | PE 859
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
COC1=CC (OCC2=NC=CC=C2) =CC=C1/C=C/C3=CC (/C=C/C4=CC5=C (C=C4) C=CN5) =NN3
Molecular Formula
C28H24N4O2
Molecular Weight
448.5157
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Indole, 6-[ (1E) -2-[5-[ (1E) -2-[2-methoxy-4- (2-pyridinylmethoxy) phenyl]ethenyl]-1H-pyrazol-3-yl]ethenyl]-
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