EPZ6438

EPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.

Product Specifications

CAS Number

1403254-99-8

Product Name Alternative

Tazemetostat

Purity

>98% (HPLC)

Solubility

DMSO: 9 mg/mL (15.71 mM)

Smiles

O=C (C1=CC (C2=CC=C (CN3CCOCC3) C=C2) =CC (N (CC) C4CCOCC4) =C1C) NCC5=C (C) C=C (C) NC5=O

Molecular Formula

C34H44N4O4

Molecular Weight

572.74

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

N- ((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl) methyl) -5- (ethyl (tetrahydro-2H-pyran-4-yl) amino) -4-methyl-4'- (morpholinomethyl) -[1,1'-biphenyl]-3-carboxamide