HJC0152
A potent, orally bioavailable STAT3 signaling inhibitor that exhibits promising antitumor effects in vitro and in vivo via inactivating STAT3 and downstream miR-21/β-catenin axis; potently inhibits MCF-7, MDA-MB-231, AsPC1 and Panc-1a cell with IC50 of 0.91, 1.64, 1.9 and 1.08 uM, respectively; suppresses HNSCC cell proliferation, arrests the cell cycle at the G0-G1 phase, induces apoptosis and reduces cell invasion in both SCC25 and CAL27 cell lines; inhibits nuclear translocation of phosphorylated STAT3 at Tyr705 and decreases VHL/β-catenin signaling activity via regulation of miR-21; suppresses MDA-MB-231 xenograft tumor growth in vivo.
Product Specifications
CAS Number
1420290-99-8
Product Name Alternative
HJC-0152 | HJC 0152
Purity
>98% (HPLC)
Solubility
DMSO: 82 mg/mL (201.7 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (NC1=CC=C ([N+] ([O-]) =O) C=C1Cl) C2=CC (Cl) =CC=C2OCCN.[H]Cl
Molecular Formula
C15H14Cl3N3O4
Molecular Weight
406.644
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (2-aminoethoxy) -5-chloro-N- (2-chloro-4-nitrophenyl) benzamide hydrochloride
Available Sizes
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