WS-6
A small molecule that can induce proliferation of β cells with EC50 of 0.28 uM; promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation; acts by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription; also stimulates α cell proliferation in human pancreatic islets.
Product Specifications
CAS Number
1421227-53-3
Product Name Alternative
WS6 | WS 6
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=CC=C (CN2CCN (C) CC2) C (C (F) (F) F) =C1) CC3=CC=C (OC4=NC=NC (NC (C5CC5) =O) =C4) C=C3
Molecular Formula
C29H31F3N6O3
Molecular Weight
568.59
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzeneacetamide, 4-[[6-[ (cyclopropylcarbonyl) amino]-4-pyrimidinyl]oxy]-N-[4-[ (4-methyl-1-piperazinyl) methyl]-3- (trifluoromethyl) phenyl]-
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