AZ5104

AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.

Product Specifications

CAS Number

1421373-98-9

Product Name Alternative

AZ5104 | AZ-5104 | AZ 5104. Demethylated AZ9291. metabolite of AZD9291

Purity

>98% (HPLC)

Solubility

Ethanol: 23 mg/mL warmed (47.36 mM) ; DMSO: 97 mg/mL (199.76 mM)

Smiles

C=CC (NC1=CC (NC2=NC=CC (C3=CNC4=C3C=CC=C4) =N2) =C (OC) C=C1N (CCN (C) C) C) =O.

Molecular Formula

C27H31N7O2

Molecular Weight

485.58

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

N- (5- ((4- (1H-indol-3-yl) pyrimidin-2-yl) amino) -2- ((2- (dimethylamino) ethyl) (methyl) amino) -4-methoxyphenyl) acrylamide

Available Sizes

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