AZ5104
AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
Product Specifications
CAS Number
1421373-98-9
Product Name Alternative
AZ5104 | AZ-5104 | AZ 5104. Demethylated AZ9291. metabolite of AZD9291
Purity
>98% (HPLC)
Solubility
Ethanol: 23 mg/mL warmed (47.36 mM) ; DMSO: 97 mg/mL (199.76 mM)
Smiles
C=CC (NC1=CC (NC2=NC=CC (C3=CNC4=C3C=CC=C4) =N2) =C (OC) C=C1N (CCN (C) C) C) =O.
Molecular Formula
C27H31N7O2
Molecular Weight
485.58
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (5- ((4- (1H-indol-3-yl) pyrimidin-2-yl) amino) -2- ((2- (dimethylamino) ethyl) (methyl) amino) -4-methoxyphenyl) acrylamide
Available Sizes
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