SP2509
SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM, shows no activity against MAOA, MAOB, LDH and glucose oxidase; inhibits the colony growth of OCI-AML3 significantly more than of the other AML cell-types, induces more apoptosis of AML cells expressing mutant NPM1 than mixed-lineage leukemia fusion oncoproteins; significantly improves the survival of immune-depleted mice model of AML, SP2509 is synergistically lethal against cultured and primary AML blasts combined with panobinostat.
Product Specifications
CAS Number
1423715-09-6
Product Name Alternative
SP-2509
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 33 mg/mL
Smiles
O=C (N/N=C (C1=CC (Cl) =CC=C1O) \C) C2=CC=CC (S (=O) (N3CCOCC3) =O) =C2
Molecular Formula
C19H20ClN3O5S
Molecular Weight
437.8972
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzoic acid, 3- (4-morpholinylsulfonyl) -, (2E) -2-[1- (5-chloro-2-hydroxyphenyl) ethylidene]hydrazide
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