Seclidemstat
Seclidemstat (SP-2577, SP2577) is a potent, selective LSD1 inhibitor with IC50 of 127 nM, reduces tumor volume in vivo. (In Vitro) :Seclidemstat (72 hours) inhibits SWI/SNF-mutation-dependent tumor cell proliferation with IC50 ranging from 0.013 to 2.819 μM (COV434, BIN67, SCCOHT-1, TOV21G, SKOV3, A427, H522, A549, H1299, G401, G402, HCC15 cells) .Seclidemstat (72 hours) promotes endogenous retroviruses (ERVs) expression and activation of IFNβ pathway in SCCOHT cell lines (SCCOHT-1, BIN67, and COV434 cells) .Seclidemstat (3 μM) promotes PD-L1 expression in SCCOHT COV 434 pIND 20 BRG1-2.7 cell line.
Product Specifications
CAS Number
1423715-37-0
Product Name Alternative
SP-2577 | SP2577
Purity
>98% (HPLC)
Solubility
DMSO: Soluble (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (N/N=C (C1=CC (Cl) =CC=C1O) \C) C2=CC=CC (S (=O) (N3CCN (C) CC3) =O) =C2
Molecular Formula
C20H23ClN4O4S
Molecular Weight
450.938
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N'-[ (1E) -1- (5-chloro-2-hydroxyphenyl) ethylidene]-3- (4-methylpiperazine-1-sulfonyl) benzohydrazide
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