IDF-11774
IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells; suppresses the mRNA expression of HIF-1 target genes VEGF and EPO but not HIF-1α; inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells; exhibits substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations.
Product Specifications
CAS Number
1429054-28-3
Product Name Alternative
IDF 11774 | IDF11774
Purity
>98% (HPLC)
Solubility
DMSO : 60 mg/mL 162.82 mM
Smiles
O=C (N1CCN (C) CC1) COC2=CC=C (C34C[C@H]5C[C@@] (C4) ([H]) C[C@H] (C5) C3) C=C2
Molecular Formula
C23H32N2O2
Molecular Weight
368.521
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (4- ((3r,5r,7r) -adamantan-1-yl) phenoxy) -1- (4-methylpiperazin-1-yl) ethan-1-one
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