ML216
ML216 (CID49852229) is a potent, selective inhibitor of DNA unwinding activity of BLM (Bloom's syndrome protein) with IC50 of 2.98 and 0.97 uM for full length BLM and BLM636-1298, respectively; weak inhibits WRN helicase (IC50=12.6 uM) and does not inhibit RecQ1, RecQ5 and UrvD (IC50>50 uM) ; disrupts BLM’s binding to DNA, rather than being an inhibitor of ATP binding by BLM, the inhibition of ssDNA-dependent ATPase activity with Ki of 1.76 uM, shows cell-based activity and can induce sister chromatid exchanges, enhances the toxicity of aphidicolin, and exerts antiproliferative activity in cells expressing BLM.
Product Specifications
CAS Number
1430213-30-1
Product Name Alternative
ML 216 | ML-216 | CID49852229
Purity
>98% (HPLC)
Solubility
DMSO: 1.71 mg/mL
Smiles
O=C (NC1=NN=C (C2=CC=NC=C2) S1) NC3=CC=C (F) C (C (F) (F) F) =C3
Molecular Formula
C15H9F4N5OS
Molecular Weight
383.3235
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N-[4-fluoro-3- (trifluoromethyl) phenyl]-N'-[5- (4-pyridinyl) -1,3,4-thiadiazol-2-yl]-
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