Sodium Nitroprusside

Sodium Nitroprusside is a potent vasodilator working through releasing NO spontaneously in blood. (In Vitro) :Sodium nitroprusside (Ro 21-2498) is a potent vasodilator. Sodium nitroprusside has potent vasodilating effects in arterioles and venules. Sodium nitroprusside breaks down in circulation to release nitric oxide (NO) . NO activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. The end result is vascular smooth muscle relaxation, which allow vessels to dilate . Sodium nitroprusside decreases the proliferation of vascular smooth muscle cells . Sodium nitroprusside (5 mg/kg) significantly reduces the intestinal ischemiareperfusion injury as a nitric oxide donor in rats .