JAK3-IN-2
A potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM; dispalys >4,300-fold selectivity over JAK1, JAK2 and TYK2, and other kinases BMX, EGFR, ITK and BTK; blocks cytokine signaling through JAK3, but not through other JAK family enzymes; inhibits IL-7 induced pSTAT5 in CD3+, CD8+ T cells with IC50 of 280 nM; sufficiently blocks the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis.
Product Specifications
CAS Number
1443235-95-7
Product Name Alternative
JAK3 inhibitor 2
Field of Research
Signal Transduction
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 260 mg/mL (742.07 mM)
Smiles
O=C (C1=CNC2=NC=NC (C3=CC=CC (NC (C (C) =C) =O) =C3) =C21) OCC
Molecular Formula
C19H18N4O3
Molecular Weight
350.378
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Ethyl 4- (3-methacrylamidophenyl) -7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
Available Sizes
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