SNG-1153
A derivate of icaritin that inhibits the growth of lung CSCs; inhibits the tumorsphere formation and decreases CD133-positive (lung CSC marker) cancer cells, attenuates tumor formation in NOD/SCID mice; induces β-catenin phosphorylation and down-regulated β-catenin; targets abnormal ERα36 activity, inhibits cell growth and induces apoptosis of BCR-ABL+ leukemic cells, particularly BCR-ABL-T315I mutant cells; effectively eliminates infiltrated BCR-ABL+ blast cells and enhances survival of mice combined with dasatinib.Breast Cancer Preclinical.
Product Specifications
CAS Number
1446712-19-1
Product Name Alternative
SNG 1153 | SNG1153
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
O=C1C (O) =C (C2=CC=C (C (F) (F) F) C=C2) OC3=C1C (O) =CC (O) =C3C/C=C (C) \C
Molecular Formula
C21H17F3O5
Molecular Weight
406.3519
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-8- (3-methyl-2-buten-1-yl) -2-[4- (trifluoromethyl) phenyl]-
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