Selonsertib
Selonsertib (GS-4997) is a highly selective and potent, ATP-competetive inhibitor of ASK1 (Apoptosis Signal-regulating Kinase 1, MAP3K5) with potential anti-inflammatory, antineoplastic and anti-fibrotic activities; orally bioavailable. Steatohepatitis, Phase 3 Clinical (In Vitro) :Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.
Product Specifications
CAS Number
1448428-04-3
Product Name Alternative
GS-4997 | GS4997 | GS 4997
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 31 mg/mL
Smiles
CC1=CC (=C (C=C1N2C=C (N=C2) C3CC3) C (=O) NC4=CC=CC (=N4) C5=NN=CN5C (C) C) F
Molecular Formula
C24H24FN7O
Molecular Weight
445.4921
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, 5- (4-cyclopropyl-1H-imidazol-1-yl) -2-fluoro-4-methyl-N-[6-[4- (1-methylethyl) -4H-1,2,4-triazol-3-yl]-2-pyridinyl]-
Available Sizes
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