SAR-20347
SAR-20347 (SAR20347) is a potent, selective inhibitor of JAK1 and Tyk2 with IC50 of 59 and 13 nM in TR-FRET assays, shows selectivity against JAK2 and JAK3 (IC50>800 nM) ; potently inhibits IL-12-mediated STAT4 phosphorylation with IC50 of 126 nM, inhibits JAK1-mediated IL-6 pSTAT3 signaling with IC50 of 345 nM in TF-1 and 407 nM in CD4+ cells, poorly inhibits JAK2 mediated STAT5 phosphorylation with IC50 of >1 uM; ameliorates imiquimod-induced psoriasis-like dermatitis in vivo.
Product Specifications
CAS Number
1450881-55-6
Product Name Alternative
SAR20347
Purity
>98% (HPLC)
Solubility
DMSO: 100 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (C1=C (NC2=CC=C (C (N3CCOCC3) =O) C=C2) OC (C4=C (F) C=CC=C4Cl) =N1) N
Molecular Formula
C21H18ClFN4O4
Molecular Weight
444.847
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (2-chloro-6-fluorophenyl) -5- ((4- (morpholine-4-carbonyl) phenyl) amino) oxazole-4-carboxamide
Available Sizes
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