Dexmedetomidine hydrochloride
An agonist of α2-adrenergic receptor that used in veterinary medicine for its analgesic and sedative properties; also protects against lung injury induced by ischemia-reperfusion through inhibition of autophagy in rats. (In Vitro) :Medetomidine has high selectivity for α2 adrenoceptors (Ki=1.08 nM) over α1 adrenoceptors (Ki=1750 nM) in rat brain membranes as measured by the displacement of [3H]clonidine.Medetomidine (0.1-100 nM) inhibits the twitch response in field-stimulated mouse vas deferens, with a pD2 of 9.0. (In Vivo) :Medetomidine (10-100 μg/kg; i.v. at 5-min intervals) produces a dose-dependent pupillary dilatation in pentobarbitone-anaesthetized rats.
Product Specifications
CAS Number
145108-58-3
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC1=C (C) C ([C@H] (C) C2=CN=CN2) =CC=C1.Cl
Molecular Formula
C13H17ClN2
Molecular Weight
236.7405
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Imidazole, 5-[ (1S) -1- (2,3-dimethylphenyl) ethyl]-, hydrochloride (1:1)
Available Sizes
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