JG-98
JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively) ; strongly affects autophagic flux, increases p62 oligomerization and reduces p62 monomer; destabilizes FoxM1 and relieved suppression of downstream effectors, including p21 and p27.
Product Specifications
CAS Number
1456551-16-8
Product Name Alternative
JG98
Purity
>98% (HPLC)
Solubility
DMSO: Soluble (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
CCN1C (=CC2=[N+] (C=CS2) CC3=CC=CC=C3) SC (=C4N (C5=C (S4) C=C (C=C5) Cl) C) C1=O.[Cl-]
Molecular Formula
C24H21Cl2N3OS3
Molecular Weight
534.532
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Thiazolium,2-[ (Z) -[ (5E) -5- (6-chloro-3-methyl-2 (3H) -benzothiazolylidene) -3-ethyl-4-oxo-2-thiazolidinylidene]methyl]-3- (phenylmethyl) -, chloride (1:1)
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
