Oxolinic acid
Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate. (In Vitro) :Oxolinic acid (2-5 ug/mL) inhibits 115 strains of E. coli.Oxolinic acid (0-31 ug/mL) inhibits 94 % of the 44 strains of Proteus mirabilis .Oxolinic acid (>5 ug/mL) inhibits all strains of Strept. Faecalis.Oxolinic acid (>2 ug/mL) causes chromosomal DNA supercoiling to decrease in the two wild-type E. coli K-12 strains tested, DM4100 and NI747.Oxolinic acid reduces chromosomal DNA supercoiling and inhibits RNA synthesis in E. coli. (In Vivo) :Oxolinic acid (32 mg/kg; i.p.) induces hyperactivity in mice.
Product Specifications
CAS Number
14698-29-4
Product Name Alternative
NSC 110364 | Urinox
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: 0.003mg/L
Smiles
O=C (C1=CN (CC) C2=CC (OCO3) =C3C=C2C1=O) O
Molecular Formula
C13H11NO5
Molecular Weight
261.24
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-Ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
Available Sizes
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