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Rosuvastatin calcium

A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM; potently inhibits cholesterol biosynthesis (IC50=1.12 nM) in rat isolated hepatocytes, 100 times more potent than pravastatin; also exerts important anti-inflammatory effects via inhibition of endothelial cell adhesion molecule expression.Dyslipidemia Approved (In Vivo) :Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms.Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Calcium (VLDL) in diabetes mellitus rats induced by Streptozocin.

Product Specifications

CAS Number

147098-20-2

Product Name Alternative

ZD-4522 calcium

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

CC (C1=NC (=NC (=C1/C=C/[C@@H] (O) C[C@@H] (O) CC (=O) [O-]) C2=CC=C (C=C2) F) N (S (=O) (=O) C) C) C.CC (C1=NC (=NC (=C1/C=C/[C@@H] (O) C[C@@H] (O) CC (=O) [O-]) C2=CC=C (C=C2) F) N (S (=O) (=O) C) C) C.[Ca+2]

Molecular Formula

C22H27Ca0.5FN3O6S

Molecular Weight

500.57

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

6-Heptenoic acid, 7-[4- (4-fluorophenyl) -6- (1-methylethyl) -2-[methyl (methylsulfonyl) amino]-5-pyrimidinyl]-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)

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