KRCA-0008
KRCA-0008 is a potent, selective ALK inhibitor with IC50 of 12 nM (wt ALK), also is potent against various ALK mutants, including L1196M, F1174L, R1275Q, and C1156Y (IC50=5-75 nM) ; weakly inhibits IR (IC50=210 nM), inhibits H3122 and BaF3 EML4-ALK L1196M cell proliferation with IC50 of 80 and 68 nM, respectively; demonstrates in vivo efficacy comparable to Crizotinib in xenograft mice model, has drug-like properties without hERG concerns.
Product Specifications
CAS Number
1472795-20-2
Product Name Alternative
KRCA 0008 | KRCA0008
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
ClC1=CN=C (NC2=CC=C (N3CCN (C (C) =O) CC3) C=C2OC) N=C1NC4=CC=C (N5CCN (C (C) =O) CC5) C=C4OC
Molecular Formula
C30H37ClN8O4
Molecular Weight
609.119
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Ethanone, 1,1'-[ (5-chloro-2,4-pyrimidinediyl) bis[imino (3-methoxy-4,1-phenylene) -4,1-piperazinediyl]]bis-
Available Sizes
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