NS-638
A nonpeptide calcium channel blocker that dose dependently inhibits AMPA-stimulated [3H]GABA-release from cultured cortical neurons with IC50 of 4.3 uM; blocks K (+) -stimulated intracellular Ca (2+) -elevation in cultured cerebellar granule cells with IC50 of 3.4 uM, reversibly blocks N- and L-type Ca (2+) -channels in cultured chick dorsal root ganglion cells (1-30 uM) ; exhibits anti-ischemic properties in vivo.
Product Specifications
CAS Number
150493-34-8
Product Name Alternative
NS638 | NS 638
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 34 mg/mL
Smiles
FC (C1=CC=C2C (N=C (N) N2CC3=CC=C (Cl) C=C3) =C1) (F) F
Molecular Formula
C15H11ClF3N3
Molecular Weight
325.7161496
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Benzimidazol-2-amine, 1-[ (4-chlorophenyl) methyl]-5- (trifluoromethyl) -
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