PF-06447475
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 of 3 and 11nM for WT LRRK2 and G2019S mutant, respectively; PF-06447475 is also sufficiently potent in the LRRK2 whole cell assay with IC50 of 25 nM; protects nerve-like differentiated cells (NLCs) against rotenone induced noxious effect, prevents α-synuclein-induced neurodegeneration in rats.
Product Specifications
CAS Number
1527473-33-1
Product Name Alternative
PF06447475
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 33 mg/mL
Smiles
N#CC1=CC=CC (C2=CNC3=NC=NC (N4CCOCC4) =C32) =C1
Molecular Formula
C17H15N5O
Molecular Weight
305.3339
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzonitrile, 3-[4- (4-morpholinyl) -7H-pyrrolo[2,3-d]pyrimidin-5-yl]-
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