A-366
A-366 is a potent, highly selective inhibitor of histone methyltransferase G9a/GLP with IC50 of 3/38 nM, >1,000-fold selectivity for G9a over 21 other methyltransferases; effects a clear reduction in H3K9 methylation in cells, shows significantly less cytotoxic effects on the growth of tumor cell lines compared to other known G9a/GLP small molecule inhibitors despite equivalent cellular activity on methylation of H3K9me2 (H3K9me2 cellular EC50=0.3 uM) ; induces differentiation and affects viability in MV4;11 cells, demonstrates growth inhibition in vivo consistent with the profile of H3K9me2 reduction in flank xenograft leukemia model.
Product Specifications
CAS Number
1527503-11-2
Product Name Alternative
A366
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
NC (C12CCC1) =NC3=C2C=C (OC) C (OCCCN4CCCC4) =C3
Molecular Formula
C19H27N3O2
Molecular Weight
329.4366
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Spiro[cyclobutane-1,3'-[3H]indol]-2'-amine, 5'-methoxy-6'-[3- (1-pyrrolidinyl) propoxy]-
Available Sizes
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