GNE-9605
GNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM; dispalys excellent selectivity against 178-membered Invitrogen kinase panel, as well as a representative panel of receptors and ion channels; demonstrates robust concentration-dependent inhibition of LRRK2 Ser1292 autophosphorylation (IC50=20 nM) in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation.
Product Specifications
CAS Number
1536200-31-3
Product Name Alternative
GNE9605 | GNE 9605
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 60 mg/mL
Smiles
FC (C1=CN=C (NC2=C (Cl) N ([C@H]3[C@H] (F) CN (C4COC4) CC3) N=C2) N=C1NC) (F) F
Molecular Formula
C17H20ClF4N7O
Molecular Weight
449.8336
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,4-Pyrimidinediamine, N2-[5-chloro-1-[ (3R,4R) -3-fluoro-1- (3-oxetanyl) -4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5- (trifluoromethyl) -, rel-
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