Serotonin hydrochloride

Serotonin hydrochloride is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist. (In Vitro) :Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki= 44 μM) . Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT. (In Vivo) :Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001) . A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin hydrochloride compare to IL-13-/- receiving vehicle following induction of DSS colitis.