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ML-323

A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM; displays >1,500-fold selectivity versus USP2, USP5, USP7, USP8, and USP46/UAF1; potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1; possesses a promising in vitro ADME profile.

Product Specifications

CAS Number

1572414-83-5

Product Name Alternative

ML323 | ML 323

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 49 mg/mL

Smiles

CC1=CN=C (C2=CC=CC=C2C (C) C) N=C1NCC3=CC=C (N4N=NC=C4) C=C3

Molecular Formula

C23H24N6

Molecular Weight

384.4769

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

N- (4- (1H-1,2,3-triazol-1-yl) benzyl) -2- (2-isopropylphenyl) -5-methylpyrimidin-4-amine

Available Sizes

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