ML-323
A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM; displays >1,500-fold selectivity versus USP2, USP5, USP7, USP8, and USP46/UAF1; potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1; possesses a promising in vitro ADME profile.
Product Specifications
CAS Number
1572414-83-5
Product Name Alternative
ML323 | ML 323
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 49 mg/mL
Smiles
CC1=CN=C (C2=CC=CC=C2C (C) C) N=C1NCC3=CC=C (N4N=NC=C4) C=C3
Molecular Formula
C23H24N6
Molecular Weight
384.4769
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (4- (1H-1,2,3-triazol-1-yl) benzyl) -2- (2-isopropylphenyl) -5-methylpyrimidin-4-amine
Available Sizes
Frequently Asked Questions
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