THZ-1
A potent, selective, covalent CDK7 inhibitor with IC50 of 3.2 nM; also weakly inhibits CDK12 with IC50 of 250 nM; displays broad-based activity a subset of cancer cell lines with IC50s of <200 nM; causes decreased cellular proliferation and an increase in apoptotic index (MCL-1, XIAP), disproportionally affects transcription of RUNX1 in Jurkat T-ALL cells; demonstrates efficacy against primary leukemia cells and in a bioluminescent xenografted model at 10mg/kg.
Product Specifications
CAS Number
1604810-83-4
Product Name Alternative
CDK7 inhibitor
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 27 mg/mL
Smiles
CN (C) CC=CC (=O) NC1=CC=C (C=C1) C (=O) NC2=CC=CC (=C2) NC3=NC=C (C (=N3) C4=CNC5=CC=CC=C54) Cl
Molecular Formula
C31H28ClN7O2
Molecular Weight
566.0527
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[3-[[5-chloro-4- (1H-indol-3-yl) -2-pyrimidinyl]amino]phenyl]-4-[[ (2E) -4- (dimethylamino) -1-oxo-2-buten-1-yl]amino]-
Available Sizes
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