Indirubin-3'-monoxime
A potent GSK3β inhibitor with IC50 of 22 nM; prevents tau phosphorylation both in vitro and in vivo; also inhibits CDKs at higher concentrations, including Cdk1/cyclin B (IC50=180 nM), Cdk2/cyclin A (IC50~500 nM), Cdk2/cyclin E (IC50=250nM), Cdk4/cyclin D1 (IC50=3.3 uM) and Cdk5/p35 (IC50=100 nM) ; reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.
Product Specifications
CAS Number
160807-49-8
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 37 mg/mL
Smiles
C1=CC=C2C (=C1) C (=C (N2) O) C3=C (C4=CC=CC=C4N3) N=O
Molecular Formula
C16H11N3O2
Molecular Weight
277.2774
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Indol-2-one, 3-[1,3-dihydro-3- (hydroxyimino) -2H-indol-2-ylidene]-1,3-dihydro-
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