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TH-588

A potent and selective inhibitor of MTH1 protein with IC50 of 5 nM; shows no relevant inhibition for MTH2, NUDT5, NUDT12, NUDT14, NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity; causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

Product Specifications

CAS Number

1609960-31-7

Product Name Alternative

TH588

Purity

>98% (HPLC)

Solubility

DMSO: 16 mg/mL

Smiles

NC1=NC (C2=CC=CC (Cl) =C2Cl) =CC (NC3CC3) =N1

Molecular Formula

C13H12Cl2N4

Molecular Weight

295.1672

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

2,4-Pyrimidinediamine, N4-cyclopropyl-6- (2,3-dichlorophenyl) -

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