TH-588
A potent and selective inhibitor of MTH1 protein with IC50 of 5 nM; shows no relevant inhibition for MTH2, NUDT5, NUDT12, NUDT14, NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity; causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
Product Specifications
CAS Number
1609960-31-7
Product Name Alternative
TH588
Purity
>98% (HPLC)
Solubility
DMSO: 16 mg/mL
Smiles
NC1=NC (C2=CC=CC (Cl) =C2Cl) =CC (NC3CC3) =N1
Molecular Formula
C13H12Cl2N4
Molecular Weight
295.1672
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,4-Pyrimidinediamine, N4-cyclopropyl-6- (2,3-dichlorophenyl) -
Available Sizes
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