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NU-2058

An ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 5 uM and 12 uM respectively; inhibits human tumor cells with a mean GI50 of 13±7 uM; reduces CDK2-mediated phosphorylation of pRb, E2F transcriptional activity and proliferatio in both anti-estrogen-sensitive and resistant cells; also inhibits DNA topoisomerase II ATPase activity (IC50=300 uM) .

Product Specifications

CAS Number

161058-83-9

Product Name Alternative

O6-cyclohexylmethyl guanine | NU2058 | NU 2058

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 32 mg/mL

Smiles

NC1=NC (OCC2CCCCC2) =C3N=CNC3=N1

Molecular Formula

C12H17N5O

Molecular Weight

247.2963

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

9H-Purin-2-amine, 6- (cyclohexylmethoxy) -

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