Cyclo (-RGDfK)
A RGD pipetide, potent and selective αvβ3 integrin inhibitor with Kd of 41.7 nM; shows strong inhibitory effect on the proliferation of T-24 cells; induces less tumor progression, less tumor metabolic activity, fewer intratumoral vessels in mice model. (In Vitro) :Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM. [66Ga]DOTA-E-[c (RGDfK) ]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation.
Product Specifications
CAS Number
161552-03-0
Product Name Alternative
Cyclo (RGDfK) peptide | Cyclic RGDfK peptide
Purity
>98% (HPLC)
Solubility
DMSO: ≥150 mg/mL
Smiles
C1C (=O) NC (C (=O) NC (C (=O) NC (C (=O) NC (C (=O) N1) CCCN=C (N) N) CCCCN) CC2=CC=CC=C2) CC (=O) O
Molecular Formula
C27H41N9O7
Molecular Weight
603.6705
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cyclo (L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-lysyl)
Available Sizes
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