EPZ015666
EPZ015666 (GSK3235025) is a potent, selective, orally available inhibitor of PRMT5 with Ki/IC50 of 5/22 nM, displays broad selectivity against a panel of other histone methyltransferases; inhibits SmD3 methylation and causes cell death in MCL cell lines (IC50=61-904 nM), demonstrates potent concentration-dependent antiproliferative effects against Z-138 and Maver-1 cells with IC50 of 96 and 450 nM, respectively; exhibits antitumor activity in multiple MCL xenograft models.
Product Specifications
CAS Number
1616391-65-1
Product Name Alternative
EPZ-015666 | GSK3235025
Purity
>98% (HPLC)
Solubility
DMSO
Smiles
O=C (C1=NC=NC (NC2COC2) =C1) NC[C@H] (O) CN3CC4=C (C=CC=C4) CC3
Molecular Formula
C20H25N5O3
Molecular Weight
383.4442
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-Pyrimidinecarboxamide, N-[ (2S) -3- (3,4-dihydro-2 (1H) -isoquinolinyl) -2-hydroxypropyl]-6- (3-oxetanylamino) -
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